Welcome Yu

Yu joined Zhu Lab as a Postdoctoral Researcher. She is interested in developing single-cell DNA damage sequencing methods to study the impacts of DNA damage repair on gene regulation during development and in diseases.

Welcome Zhenkun

Zhenkun joined Zhu Lab as a Graduate Student. He is interested in developing novel genomics tools to understand the molecular mechanism underlying neurological disorders.

Welcome Xiaonan

Xiaonan joined Zhu Lab as a Postdoctoral Research Associate. She is interested in investigating the epigenetic pathological mechanisms of neurological diseases.

Welcome Xiuzhen

Xiuzhen joined Zhu Lab as a Postdoctoral Research Associate. She is interested in developing single-cell multiomics and epigenomics technologies to elucidate the genetic and epigenetic changes related to human disease.

SIMPLE-seq jointly measures 5mC and 5hmC from single cells

Collaborating with Dr. Chengqi Yi from Peking University, we developed SIMPLE-seq technology for joint analysis of 5mC and 5hmC from single cells. This approach uses two orthogonal chemical labeling reactions to sequentially convert the targeted modification. SIMPLE-seq identified the potential "intermediate" cell population by pinpointing cells with more disordered 5mC-5hmC relationships and facilitated the characterization of methylation landscapes from complex tissue samples.

Welcome Xiaomeng

Xiaomeng joined Zhu Lab as a Postdoctoral Research Associate. She is interested in the development and application of computational single-cell methods to dissect the dynamic gene regulation program.

Chenxu receives NIH Director's New Innovator Award

Chenxu has been awarded the National Institutes of Health Director's New Innovator Award. Funded by the National Institute of General Medical Sciences, we will develop single-cell multiomics tools to measure cells' "regulatory dyanmics" and identify the molecular changes of aging in the mouse brain.

Paired-Tag, now in droplets! 

We report Droplet Paired-Tag, a rapid and robust method to simultaneously profile histone modifications and gene expression in single cells at scale. Droplet Paired-Tag provides researchers with a tool for studying the epigenome and gene regulation in complex tissues and disease pathogenesis.

Welcome Robert

Robert joined Zhu Lab as a Research Associate to develop single-cell multiomics techniques to study the functions and structures of genome.

Welcome Boshi

Boshi joined Zhu Lab as a Postdoctoral Associate to develop novel single-cell analysis techniques and proteomics methods for elucidating the biological roles of non-canonical nucleic acid motifs.

Welcome Nivedita

Nivedita is a Research Associate in the Zhu Lab. She is interested in the development and application of single-cell genomics technologies in studying gene regulation programs during cell differentiation.

Welcome Xuming and Dongsheng

Xuming is a Postdoctoral Associate at Dr. Shuibing Chen's lab at Weill Cornell Medicine. He joined Zhu Lab as a Visiting Scientist. He will use single-cell multiomics genomics technologies to study the gene regulation mechanisms during stem cell differentiation.

Dongsheng recently obtained his Ph.D. from Peking University. He joined Zhu Lab as a Postdoctoral Researcher. He is interested in developing innovative multi-omics and spatial-omics tools to study DNA or histone marks related to genome integrity and flexibility during aging and in neurodegenerative disorders.

Zhu Lab is now open!

Chenxu started at NYGC and WCM on 4/25. The Zhu Lab is open now!

Zhu Lab will start in 2022 at NYGC and WCM!

Chenxu will join New York Genome Center as a Core Member and Weill Cornell Medicine as an Assistant Professor in 2022. The Zhu Lab will develop and apply multimodal single-cell genomics tools to study development, aging and age-related diseases.

We are seeking for talented scientists at all levels! The lab will be based at the New York Genome Center located in lower Manhattan. Learn more about our research, and Join us!